[Indian Journal of Physiology and Pharmacology (1998): (42), 4, 527]
نویسندگان
چکیده
The study was carried out in rabbits, to see the effect of Septilin, a herbal preparation on the single and multiple dose kinetics of carbamazepine. Single dose treatment of Septilin significantly decreased t 1⁄2a. t 1/2e. AUCo-α of carbamazepine. Steady state Cmax and AUC0-24 of carbamazepine also reduced significantly in comparison to those of control rabbits after 7 days coadministration of Septilin. We can be conclude that Septilin decrease/hinder the absorption process of carbamazepine through an unknown mechanism.
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